The Best Who Has The Most Home Runs In One Season Ideas. Most home runs in a season: Barry bonds, 73, 2001 2.

With that in mind, here is a look at the most leadoff homers hit by a player in a single season, through 2018. Who has hit 50 home runs in four consecutive seasons? (630), jim thome (612), and sammy sosa (609) are the only other players to have hit 600 or more.